AASHTOWare Pavement ME Design is the next generation of pavement design software. It is built upon the NCHRP mechanistic-empirical pavement design guide and expands and improves the features of the accompanying prototype computational software. AASHTOWare Pavement ME Design is a production-ready software tool to support the day-to-day operations of public and private pavement engineers. It calculates pavement responses (stresses, strains, and deflections) and combines them with other pavement, traffic, climate, and materials parameters to predict the progression of key pavement distresses and smoothness loss over time for hot-mix asphalt (HMA) and Portland cement concrete (PCC) pavements. These outputs are the basis for checking the adequacy of a trial design. AASHTOWare Pavement ME Design is a powerful program that incorporates a user-friendly interface with several functional, stability, and performance enhancements, such as improved runtime, automatic update notification, an SI version, inclusion of highway capacity limits, climate data viewers and climate summaries, batch processing, multi-project editing, project compare tool, error checking for individual inputs and forms, provisions for sensitivity analysis, thickness optimization, ability to import back-calculation data, database functionality at enterprise and workstation level, a structural response query tool, and improved reporting. For many pavement engineers, it is a paradigm shift away from a nomograph-based design to one based on engineering principles and mechanics. Instead of entering the basic site and project information into an equation and getting an empirically based pavement design output, the engineer can use detailed traffic, materials and environmental information to assess the short and long-term performance of a pavement design using nationally and/or locally calibrated models. This software is a comprehensive pavement design and analysis tool, capable of providing support and insights to highway decision-makers, academia and consultants. This state-of-the-practice tool represents the current advancements in pavement design. It also provides tools to generate optimized pavement design based on given requirements allowing the user to evaluate and fine-tune the design. The database utility allows users to save final designs as well as individual input parameters such that these can subsequently be used for future designs, various distress and performance analyses, and for other management purposes. AASHTOWare Pavement ME Design reflects a change in the methods and procedures engineers use to design pavement structures. It takes advantage of the advances in material mechanics, axle-load spectra and climate data for predicting pavement performance. While this software does not answer all of the challenges to pavement design, it is a quantum leap forward from previous pavement design procedures and facilitates future development in pavement modelling and analysis.